IN VIVO ASSESSMENT OF SKIN IMPEDANCE RECOVERY AFTER LOW-VOLTAGE PULSES ELECTROPORATION

Pasquale Arpaia, Fabrizio Clemente, Carlo Manna

Abstract

The aim of this work is to measure the skin impedance recovery after electroporation by using low-voltage pulse protocol on human subject. Before and after electroporation, based on square wave pulses of 20-50 V, 5 μs, for 15-20 minutes, Electrical Impedance Spectroscopy (EIS) measurements has been performed, in the frequency range 0.5-10 kHz. Preliminary experimental results show a significant decrease in skin impedance amplitude after treatment. This result turns out to be useful in a measurement procedure aimed at determining the amount of drug actually transferred in electroporation-based therapy.

Download: IMEKO-TC4-2008-179.pdf
DOI: -
IMEKO TC: TC4 - Measurement of Electrical Quantities

Event details

Event: Exploring New Frontiers of Instrumentation and Methods for Electrical and Electronic Measurements
Technical Committee: TC4
Place: Florence, ITALY
Time: 22 September 2008 - 24 September 2008
Website: http://www.imeko2008.org/

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