EVALUATION OF OPTICAL SIGNALS FOR DNA CHAIN ANALYSIS

A. Cysewska-Sobusiak, M. Boltrukiewicz

Abstract

The molecular complementarity of the two strands of the DNA double helix makes it possible to model changes in DNA sequences manifesting by related changes in their melting temperature, thermodynamic data and optical properties. The subject of the paper is focused on metrological problems connected with modeling of a virtual integrated oligonucleotide library, basing on the analysis of fluorescence signals to be obtained as a result of hybridization.

Keywords

oligonucleotide biooptics, modeling and simulation

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IMEKO-WC-2000-TC13-P331.pdf

DOI

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IMEKO TC

TC13 - Measurements in Biology and Medicine

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