Carbon/polymer hybrid bio-sensors for neurotransmitters analysis

Cristina Schreiner, Gabriel Dimofte, Thomas Schreiner

Abstract

A new concept of hybrid bio-sensors are proposed for collecting microfluidic probes, in order to study and treat neurological disorders. The micro-electrode features at nanoscale are based on incorporating via electropolymerization of oxidized conjugated polymer - as charge-balancing - with dopants (e.g. Pyrrole derivatives, PEDOT, ProDOT, ProDOP and their copolymers), at the surface of carbon structures with nanopores of predefined architectures. The mechanical, fatigue and adhesion properties of the experimental coatings were assessed by using nanoindentation, high frequency impact and scratch specific tests. The electrochemical characterization (Potentiostat/Galvanostat method) was performed by using reference redox molecules such as ferricyanide, p-aminophenol, hydroquinone etc. Some applications were emphasized by testing the sensors sensitivity and reproducibility at different concentrations of dopamine, epinephrine and norepinephrine in acid medium (0.1 M HCl). In order to tailor the hybrid bio-sensors for medical applications, the potential interferences within biological samples of ascorbic acid, uric acid etc. were also taken into account. Finally, a functional on-chip model was developed, by integrating: interaction area (microelectrode exposure array), detection area (detection circuits) and processing and transmission area (signal processing and communication features).

Keywords

conductive polymers, carbon nanostructures, hybrid bio-sensors, neurotransmitters detection

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DOI

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IMEKO TC

TC4 - Measurement of Electrical Quantities

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