Determination of Trace Elements in Blood by Total Reflection X-ray Fluorescence (TXRF) Analysis

Haile Dennis, Charles Grant, Tracey-Ann Warner, Gerald Lalor

Abstract

Baseline elemental concentrations in blood samples from healthy Jamaicans were determined using total reflection x- ray fluorescence (TXRF) spectroscopy. The mean concentrations of Cu, Fe, P, Rb, S, Se and Zn of the cohort were found to be 92, 36045, 21930, 199, 147106, 10, 1211 µg/dL respectively. Except for Rb (lower) and Zn (higher) these are similar to values observed worldwide. The mean concentrations of P, S, Fe, Se and Rb in males were significantly different from those in females with males having higher concentrations of all elements determined except Rb. TXRF has demonstrated its ability to measure trace concentrations with accuracy and precision high enough to identify differences within a seemingly similar population of men and women and to identify sub populations within each of these. This technique promises possible studies into the effect of trace elements on various medical disorders such as cancer, diabetes, hypertension and heart diseases among others in Jamaica and other countries.

Keywords

whole blood, trace elements, TXRF, gender

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IMEKO TC

TC19 - Environmental Measurements

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