MEASUREMENT RELIABILITY IN HORSERACING LABORATORY OPERATION

India Maria H. de Lima, Maurício N. Frota

Abstract

Abstract: Similar to many other testing laboratory activities, horseracing laboratory’s operation requires formal recognition of measurement results, mainly to establish the presence of a wider range of prohibited substances (low concentrations) in biological matrices. The objective of this work is twofold: (i) the qualitative and semi-quantitative assessment of various substances detected among all (over 50,000) racehorses’ urine analytical analysis conducted by the Antidoping Laboratory of the Brazilian Jockey Club (LAD/JCB) between 1996 and 2005 to identify the most frequent prohibited substances marked as ‘forbidden’ on the list of Brazilian National Horseracing Code (CNC) and (ii) to develop and validate an specific mass spectrometry analytical method for the routine determination of traces of doping by caffeine. Caffeine confirmed to be the most common doping substance used in the Brazilian horseracing activity in 2002 when this investigation started. The tailored made analytical method developed (ALCAC-18), ensuring that false-negative’ results are kept to a minimum, was then validated for the determination of caffeine.

Keywords

horseracing doping, metrology reliability, caffeine, mass spectrometry analytical method, metrology in chemistry

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PWC-2006-TC8-009u.pdf

DOI

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IMEKO TC

TC8 - Traceability in Metrology

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