Design Optimization of a Photoacoustic System for Gas Detection in Exhaled Breath

Marco Muzzarelli, Giovanni Gibertoni, Daniele Goldoni, Ali Marzdar, Enza Panzardi, Marco Grassi, Piero Malcovati, Marco Mugnaini, Luigi Rovati

Abstract

Exhaled breath analysis is a promising non-invasive approach for detecting disease-related biomarkers, including nitrogen dioxide (NO₂), which is associated with airway inflammation. A compact photoacoustic spectroscopy (PAS) system was developed using a 405 nm LED source and a resonant acoustic chamber optimized for NO₂ detection. Focused optical excitation enhances localized absorption, generating an acoustic signal detected by a MEMS microphone. The system demonstrated a good response to 50 ppm gas variation, supporting its suitability for low-cost breath analysis applications.

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IMEKO-TC2-2025-004.pdf

DOI

10.21014/tc2-2025.004

IMEKO TC

TC2 - Photonics

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