Drug Under Skin Meter (DUSM): a portable bio-impedance spectroscope for assessing transdermal drug delivery |
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| Pasquale Arpaia, Pasquale Cimmino, Umberto Cesaro, Nicola Moccaldi |
- Abstract:
- An instrument prototype, based on a measurement method relating bioimpedance and amount of drug present in a tissue under test, was realized. The instrument assesses the amount of drug conveyed through the skin by measuring impedance spectrum before and after administration. In compliance with safety regulations, the stimulus signal does not exceed the peak value of 200 µA well below the threshold of 424 µA provided by the IEC-60601 standard. In this paper, after illustrating the conceptual and physical design of hardware, firmware, and software interface, a preliminary metrological characterization of the prototype is described. This realization opens interesting scenarios to pursue strategies of immediate efficacy assessment for all non-invasive systems for intradermal conveying.
- Download:
- IMEKO-TC10-2016-011.pdf
- DOI:
- -
- Event details
- IMEKO TC:
- TC10
- Event name:
- TC10 Workshop on Technical Diagnostics 2016
- Title:
14th IMEKO TC10 Workshop “New Perspectives in Measurements, Tools and Techniques for system’s reliability, maintainability and safety”
- Place:
- Milano, ITALY
- Time:
- 27 June 2016 - 28 June 2016